Oral squamous cell carcinoma patients which human papilloma virus infection: a case control study in Muwardi Hospital Surakarta, Central Java, Indonesia

Adi Prayitno, Elyana Aznar, Poernomo, Suhartono Taat Putra

Abstract. Prayitno A, Aznar E, Poernomo, Putra ST. 2011. Oral squamous cell carcinoma patients which human papilloma virus infection: a case control study in Muwardi Hospital Surakarta, Central Java, Indonesia. Nusantara Bioscience 3: 64-67. Annual incidence rates for oral and pharyngeal cancer are estimated at 25 cases per 100,000 in developing countries. Human papilloma virus (HPV) was implicated in pathogenesis of Oral Squamous Cell Carcinoma (OSCC). Aims of this research were to know the incidence of OSSC patient which realized HPV infection. Women OSCC (15) and Benign Oral Squamous Cells (BOSC) (40) tissue biopsy frozen sections were from Departement of Oral and Dental, Muwardi Hospital in Surakarta from January to December 2007. Tissue was cut into two parts. To ascertain the type of neoplasm was subsequently stains with HE. To amplify the L1-HPV gene for 450bp long. The collected data was analyzed by Chi Square Test. The result of this experiment showed nine patients from 40 patients BOSC identified have HPV infections (9/40 = 23%). Eleven patient from 15 patient OSCC identified have HPV infections (11/15 = 73%). From Chi Square analysis have significant differences between BOSC and OSCC. HPV is a factor for OSCC pathogenesis.

Key words: developing countries, HPV, pathogenesis, OSCC, Moewardi Hospital.

Abstrak. Prayitno A, Aznar E, Poernomo, Putra ST. 2011. Pasien oral squamous cell carcinoma dengan infeksi virus papiloma manusia: studi kasus kontrol di Rumah Sakit Muwardi Surakarta, Jawa Tengah, Indonesia. Nusantara Bioscience 3: 64-67. Tingkat insiden tahunan untuk kanker mulut dan faring diperkirakan mencapai 25 kasus per 100.000 di negara-negara berkembang. Human papilloma virus (HPV) terlibat dalam patogenesis Oral Squamous Cell Carcinoma (OSCC). Tujuan penelitian ini adalah untuk mengetahui kejadian pasien OSSC yang mengalami infeksi HPV. Irisan beku biopsi jaringan OSCC (15) dan Benign Oral Squamous Cells (BOSC) (40) wanita diperoleh dari Bahian Mulut dan Gigi Rumah Sakit Muwardi Surakarta, dari bulan Januari sampai Desember 2007. Jaringan dipotong menjadi dua bagian. Untuk memastikan jenis neoplasma, maka diwarnai dengan HE. Untuk gen L1-HPV digunakan penanda berukuran 450bp. Data yang dikumpulkan dianalisis dengan Chi Square Test. Hasil penelitian ini menunjukkan sembilan pasien dari 40 pasien BOSC diidentifikasi mengalami infeksi HPV (9/40 = 23%). Sebelas pasien dari 15 pasien OSCC diidentifikasi mengalami infeksi HPV (11/15 = 73%). Dari analisis Chi Square terdapat perbedaan yang signifikan antara BOSC dan OSCC. HPV merupakan faktor patogenesis OSCC.

Kata kunci: negara berkembang, HPV, patogenesis, OSCC, Rumah sakit Muwardi.

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